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Resveratrol

Resveratrol

Resveratrol is a plant compound found in red grapes, berries, and peanuts that acts as both an antioxidant and a signaling molecule. Inside the body, it helps reduce oxidative stress and inflammation, and it can activate some of the same longevity pathways as NAD, particularly sirtuins. Researchers became interested in resveratrol when they noticed it could mimic some of the cellular effects of calorie restriction — a proven way to extend lifespan in animals.

Does it really work?

In animals, resveratrol has repeatedly been shown to activate sirtuins, improve mitochondrial function, and extend lifespan under certain conditions. In humans, the picture is more limited. Small clinical studies suggest resveratrol may improve insulin sensitivity, blood vessel function, and markers of inflammation, but the results are mixed and often depend on dose and formulation. While it clearly acts as an antioxidant, its role in human longevity is still unproven, and the doses needed for meaningful effects may be higher than what’s practical from diet alone.

Can I get enough in real food?

Resveratrol is found naturally in red grapes, red wine, blueberries, cranberries, and peanuts. These foods can contribute small amounts, but the levels are modest — a glass of red wine, for example, contains only a few milligrams. Most human studies use doses hundreds of times higher than what you’d get from food, which means dietary sources alone aren’t enough to reach the levels tested for health benefits.

Do I need a supplement for everyday health?

For general health, you don’t need a resveratrol supplement — eating a variety of colorful fruits, vegetables, and other polyphenol-rich foods gives you a broad spectrum of antioxidants and plant compounds. Resveratrol supplements are mainly of interest for people focused on longevity research, since they may activate the same pathways as calorie restriction. However, the evidence in humans is still early, and benefits for lifespan or aging have not been proven. If used, resveratrol should be seen as an experimental add-on, not a core supplement.