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Fisetin

Fisetin

Fisetin is a plant flavonoid found in strawberries, apples, onions, and cucumbers. Beyond its antioxidant effects, fisetin is being studied as a senolytic — a compound that helps the body clear out “senescent cells.” These are older, damaged cells that stop dividing but don’t die, and they can release inflammatory signals that accelerate aging. By helping remove these worn-out cells, fisetin may improve tissue function and support healthier aging at the cellular level.

Does it really work?

In lab and animal studies, fisetin has shown strong senolytic activity, helping clear senescent cells and extending lifespan in mice. This has made it one of the most promising compounds in aging research. In humans, though, the evidence is still very limited. A few small clinical trials are underway, but results have not yet confirmed whether fisetin meaningfully clears senescent cells or improves health outcomes in people. For now, its antioxidant effects are proven, but its senolytic role in humans remains emerging and unproven.

Can I get enough in real food?

Yes — fisetin is naturally found in strawberries, apples, persimmons, onions, and cucumbers. Strawberries are the richest source, but even then, the amounts are very small compared to the doses used in research. You would need to eat pounds of strawberries daily to reach the levels tested for senolytic effects. That means while food sources contribute to overall intake, they aren’t enough to achieve the higher doses studied for anti-aging benefits.

Do I need a supplement for everyday health?

For general health, fisetin from fruits and vegetables contributes to your antioxidant intake, but you don’t need a supplement to get those benefits. Fisetin in capsule form is mostly of interest to people following the emerging science on senolytics and longevity. Because human research is still in the early stages, fisetin supplements should be seen as experimental — promising in animals, but not yet proven in people.